The Cubs are without outfielder Anthony Rizos injury.
Manager Joe Maddon said Rizzos “has a little inflammation in his knee.”
Maddon is not sure if Rizomos left the game in the first inning or if the injury is more serious.
“It was a little discomfort,” Maddon told reporters.
Rizombs injury is the second major injury for Maddon this year, the Cubs are 1-2.
The right-hander is batting .200 with five homers, eight RBIs and seven runs scored in his last three starts.
Maddon has called up 22 players this season, including Rizzombs right-handed batman.
He said Rizoms status was “unknown” but that he is expected to be available to start the Cubs season opener against the Kansas City Royals.
The Cubs announced on Tuesday that outfielder Jorge Soler was transferred from Triple-A Iowa to the 60-day disabled list.
Soler had been with the Cubs since April 15, but he has missed nine games due to inflammation in the left knee.
Cubs president Theo Epstein has called Soler a “proven commodity” who was acquired in July from the Atlanta Braves.
Solers knee issues are not the first for Soler.
In 2015, he was hit by a pitch from Cincinnati Reds shortstop Zack Cozart.
Soleri’s manager, Mike Matheny, said Soler’s knee had to be “surgicalized.”
Soler also has played for the St. Louis Cardinals, Oakland Athletics and Milwaukee Brewers.